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<正>剖宫产最常用麻醉方式为椎管内麻醉,对于一些椎管内麻醉禁忌的产妇,全身麻醉则成为首选。麻醉方式与药物的选择不仅会影响产妇,也可对胎儿造成不良影响,甚至威胁生命。瑞芬太尼半衰期短,通过胎盘后可迅速代谢,相比其他阿片药物在剖宫产中安全性高[1],已成为剖宫产全身麻醉常用的镇痛药[2]。然而,瑞芬太尼可引起严重心动过缓、低血压,导致重要脏器灌注不足;甚至可引起新生儿呼吸抑制[3]。艾司氯胺酮具有呼吸抑制轻、循环轻度兴奋、舒张支气管作用,同时还可改善产妇产后抑郁情绪[4],理论上讲更适合剖宫产患者的全身麻醉诱导。本次研究探讨艾司氯胺酮与瑞芬太尼诱导对全身麻醉剖宫产产妇及胎儿的影响。现报道如下。
Abstract:1 Kart K,Hanci A.Effects of remifentanil and dexmedetomidine on the mother’s awareness and neonatal Apgar scores in caesarean section under general anaesthesia[J].J Int Med Res,2018,46(5):1846-1854.
2 Sigaut S,Eurin M,Fauquenot C,et al.Choice of anaesthetic agents for caesarean section under general anaesthesia:A French national survey of current practices[J].Int J Obstet Anesth,2020,41:115-118.
3 鲜潋艳,李盛.丙泊酚复合瑞芬太尼靶控输注全身麻醉对剖宫产新生儿安全性的影响[J].医学理论与实践,2017,30(5):727-728.
4 Kim J,Farchione T,Potter A,et al.Esketamine for treatment-resistant depression:First FDA-approved antidepressant in a new class[J].N Engl J Med,2019,381(1):1-4.
5 张洁,周仁龙,王珊娟.瑞芬太尼在产科麻醉中的应用[J].上海医学,2011,34(8):638-640.
6 姚罡.艾司氯胺酮诱导全身麻醉剖宫产术新生儿Apgar评分影响:一项倾向性评分分析[J].实用妇科内分泌电子杂志,2020,8(22):53-54.
7 Xu LL,Wang C,Deng CM,et al. Efficacy and safety of esketamine for supplemental analgesia during elective cesarean delivery:A randomized clinical trial[J]. JAMA Netw Open,2023,6(4):e239321.
8 Fitzgerald JP,Fedoruk KA,Jadin SM,et al.Prevention of hypotension after spinal anaesthesia for caesarean section:A systematic review and network meta-analysis of randomised controlled trials[J].Anaesthesia,2020,75(1):109-121.
9 李永乐,陈祥楠,方琴,等.不同剂量的艾司氯胺酮在剖宫产全身麻醉诱导中的应用[J].中国新药与临床杂志,2023,42(2):136-140.
10 Singh JB,Fedgchin M,Daly E,et al. Intravenous esketamine inadult treatment-resistant depression:A doubleblind,double-randomization,placebo-controlled study[J].Biol Psychiatry,2016,80(6):424-431.
基本信息:
DOI:10.13558/j.cnki.issn1672-3686.2025.001.021
中图分类号:R614
引用信息:
[1]袁兴,李爱梅,刘中光.艾司氯胺酮与瑞芬太尼在全身麻醉剖宫产手术中的应用比较[J].全科医学临床与教育,2025,23(01):74-76.DOI:10.13558/j.cnki.issn1672-3686.2025.001.021.
2025-01-26
2025-01-26