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2025, 11, v.23 1025-1028+1044
子痫前期药物预防及剖宫产麻醉研究进展
基金项目(Foundation): 2023年度市级指导性科技攻关项目(2023ZD043)
邮箱(Email):
DOI: 10.13558/j.cnki.issn1672-3686.2025.011.017
摘要:

<正>子痫前期是以妊娠20周后新发高血压伴蛋白尿或器官功能障碍为特征的严重妊娠期并发症。随病情发展,患者可出现子痫、HELLP综合征或多器官功能衰竭等严重不良事件,被认为是导致全球孕产妇及围产儿死亡的主要原因[1]。流行病学数据显示,全球子痫前期发病率约为2%~8%[2],中国发病率约为2.3%[3],提醒我国防控子痫前期的急迫。子痫前期临床表现多样,包括头痛、视觉障碍、上腹疼痛及水肿等,其危害不仅限于妊娠期,还可能增加产妇远期心血管疾病及子代代谢异常风险[4]。因此,早期识别子痫前期高危人群并采取有效防控措施,对改善母婴结局至关重要。

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参考文献

1 Overton E,Tobes D,Lee A.Preeclampsia diagnosis andmanagement[J].Best Pract Res Clin Anaesthesiol,2022,36(1):107-121.

2 Ives CW,Sinkey R,Rajapreyar I,et al. Preeclampsia-Pathophysiology and clinical presentations:JACC state-of-the-art review[J]. J Am Coll Cardiol,2020,76(14):1690-1702.

3 Yang Y,Le Ray I,Zhu J,et al.Preeclampsia prevalence,risk factors,and pregnancy outcomes in Sweden and Chi-na[J].JAMA Netw Open,2021,4(5):e218401.

4 Turbeville HR,Sasser JM.Preeclampsia beyond pregnan-cy:Long-term consequences for mother and child[J].AmJ Physiol Renal Physiol,2020,318(6):F1315-F1326.

5郭小明,唐显赫,宁书芬.不同麻醉方法对重度子痫前期患者产后的影响[J].中国煤炭工业医学杂志,2023,26(6):658-662.

6 Hofmeyr R,Matjila M,Dyer R. Preeclampsia in 2017:Obstetric and anaesthesia management[J].Best Pract ResClin Anaesthesiol,2017,31(1):125-138.

7 Rana S,Lemoine E,Granger JP,et al. Preeclampsia:Pathophysiology,challenges,and perspectives[J].Circ Res,2019,124(7):1094-1112.

8 Opichka MA,Rappelt MW,Gutterman DD,et al.Vasculardysfunction in preeclampsia[J].Cells,2021,10(11):3055.

9 Luo F,Liu F,Guo Y,et al.Single-cell profiling revealsimmune disturbances landscape and HLA-F-mediatedimmune tolerance at the maternal-fetal interface in pre-eclampsia[J].Front Immuno,2023,14:1234577.

10程备,段茉莉,丁桂凤.乌鲁木齐市子痫前期发病的高危因素分析及Nomogram预测模型的构建与验证[J].现代预防医学,2024,51(11):1938-1943.

11马翠,刘晓巍,郑媛媛,等.孕妇及其子代ERAP-1基因多态性与子痫前期发生的相关性[J].中华妇产科杂志,2024,59(6):434-439.

12赖春池,张璐璐,孙梦雅,等.HLA-DRB1基因多态性与早发型重度子痫前期遗传易感性的研究[J].中国当代儿科杂志,2023,25(10):1022-1027.

13谭家余,黄湘,钟苑芳,等.SDC1基因单核苷酸多态性与汉族孕产妇伴有严重特征的子痫前期易感性相关性研究[J].现代妇产科进展,2024,33(11):830-833,837.

14 Poon LC,Shennan A,Hyett JA,et al. The internationalfederation of gynecology and obstetrics(FIGO) initia-tive on pre-eclampsia:A pragmatic guide for first-tri-mester screening and prevention[J]. Int J Gynaecol Ob-stet,2019,145(Suppl 1):1-33.

15 Fiala C,Pasic MD.Aspirin:Bitter pill or miracle drug?[J].Clin Biochem,2020,85:1-4.

16 ACOG Committee. Opinion No. 743:Low-dose aspirinuse during pregnancy[J]. Obstet Gynecol,2018,132(1):e44-e52.

17中华医学会妇产科学分会妊娠期高血压疾病学组.妊娠期高血压疾病诊治指南(2020)[J].中华妇产科杂志,2020,55(4):227-238.

18 World Health Organization.WHO recommendations on an-tiplatelet agents for the prevention of pre-eclampsia[EB/OL].(2021-12-06)[2021-12-20].https://www.who.int/pub-lications/i/item/9789240037540.

19 Guo Y,Zhu Y,Sun Y,et al.The preventive effect of low-dose aspirin in a PPAR-γ antagonist treated mousemodel of preeclampsia[J]. BMC Pregnancy Childbirth,2022,22(1):606.

20 Rolnik DL,Nicolaides KH,Poon LC. Prevention of pre-eclampsia with aspirin[J].Am J Obstet Gynecol,2022,226(2S):S1108-S1119.

21 Chen X,Yang Y,Chen L,et al.Pregnancy outcomes andbirth defects in offspring following Non-steroidal anti-in-flammatory drugs exposure during pregnancy:A system-atic review and meta-analysis[J]. Reprod Toxicol,2024,125:108561.

22 D'Ambrosio V,Vena F,Scopelliti A,et al.Use of non-ste-roidal anti-inflammatory drugs in pregnancy and oligohy-dramnios:A review[J]. J Matern Fetal Neonatal Med,2023,36(2):2253956.

23 Markovic M,Swanson SA,Stricker BH,et al.Prenatal ex-posure to non-steroidal anti-inflammatory drugs(NSAIDs) and neurodevelopmental outcomes in children[J].Pharmacoepidemiol Drug Saf,2019,28(4):452-459.

24 Cruz-Lemini M,Vázquez JC,Ullmo J,et al.Low-molecu-lar-weight heparin for prevention of preeclampsia andother placenta-mediated complications:A systematic re-view and meta-analysis[J]. Am J Obstet Gynecol,2022,226(2S):S1126-S1144.e17.

25 Yinon Y,Ben Meir E,Margolis L,et al.Low molecularweight heparin therapy during pregnancy is associatedwith elevated circulatory levels of placental growth factor[J].Placenta,2015,36(2):121-124.

26 Romero R,Erez O,Hüttemann M,et al.Metformin,the as-pirin of the 21 st century:Its role in gestational diabe-tes mellitus,prevention of preeclampsia and cancer,andthe promotion of longevity[J].Am J Obstet Gynecol,2017,217(3):282-302.

27 Fox KA,Longo M,Tamayo E,et al.Effects of pravastatinon mediators of vascular function in a mouse model ofsoluble Fms-like tyrosine kinase-1-induced preeclampsia[J].Am J Obstet Gynecol,2011,205(4):366.e1-5.

28 Vahedian-Azimi A,Karimi L,Reiner?,et al.Effects ofstatins on preeclampsia:A systematic review[J].Pregnan-cy Hypertens,2021,23:123-130.

29康昕,杨慧霞.两项关于妊娠期小剂量补钙的随机试验[J].中华围产医学杂志,2024,27(2):157.

30 Khaing W,Vallibhakara SA,Tantrakul V,et al.Calciumand Vitamin D supplementation for prevention of pre-eclampsia:A systematic review and network meta-analy-sis[J].Nutrients,2017,9(10):1141.

31 World Health Organization.WHO recommendation on Cal-cium supplementation before pregnancy for the preven-tion of pre-eclampsia and its complications.2020[EB/OL].(2020)[2020-04-15]. https://apps. who. int/iris/bitstream/handle/10665/331787/9789240003118-eng.pdf.

32郭琳琼,吉婷,刘星.钙剂联合小剂量阿司匹林对子痫前期的预防效果[J].陕西医学杂志,2017,46(6):803-804.

33 Chen WY,Sun SF.Clinical efficacy of low-dose aspirincombined with calcium in preventing preeclampsia:Asystematic review and meta-analysis[J]. Medicine(Balti-more),2023,102(34):e34620.

34 Dennis AT,Xin A,Farber MK.Perioperative managementof patients with preeclampsia:A comprehensive review[J].Anesthesiology,2025,142(2):378-402.

35 Hood DD.Spinal anesthesia is the preferred techniquefor cesarean section in severe preeclampsia:Proponentposition[J].Acta Anaesthesiol Belg,2002,53(4):305-310.

36 Andersson ML,Lindelof K,Wikkels?A. Anaesthesiologi-cal management of pre-eclampsia and eclampsia[J]. Ug-eskr Laeger,2024,186(38):V05240333.

37 Berends N,Teunkens A,Vandermeersch E,et al.A ran-domized trial comparing low-dose combined spinal-epi-dural anesthesia and conventional epidural anesthesiafor cesarean section in severe preeclampsia[J].Acta An-aesthesiol Belg,2005,56(2):155-162.

基本信息:

DOI:10.13558/j.cnki.issn1672-3686.2025.011.017

中图分类号:R614;R714.244

引用信息:

[1]徐晨湛,游金凤,赖凯丽.子痫前期药物预防及剖宫产麻醉研究进展[J].全科医学临床与教育,2025,23(11):1025-1028+1044.DOI:10.13558/j.cnki.issn1672-3686.2025.011.017.

基金信息:

2023年度市级指导性科技攻关项目(2023ZD043)

发布时间:

2025-11-28

出版时间:

2025-11-28

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